| Identification |
|---|
| BMDB Protein ID
| BMDBP02600 |
| Secondary Accession Numbers
| None |
| Name
| Proto-oncogene vav |
| Synonyms
|
Not Available
|
| Gene Name
| VAV1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in diacylglycerol binding |
| Specific Function
| Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| Pathways
|
- BCR Signaling Pathway
- Fc Epsilon Receptor I Signaling in Mast Cells
- Phospholipase C Signaling Pathway
- Phospholipase C Signaling Pathway
- Rac 1 cell motility signaling pathway
- Rac 1 Cell Motility Signaling Pathway
- Ras Signaling Pathway
- T Cell Receptor Signaling Pathway
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| VAV1 |
| Gene Sequence
|
>2535 bp
ATGGAGCTGTGGCGCCAGTGCACCCACTGGCTCATCCAGTGCCGGGTGCTACCGCCCAGC
CACCGTGTGACCTGGGATGGAGCCCAAGTGTGCGAGCTGGCGCAGGCCCTCCGGGATGGC
GTCCTTCTGTGCCAGCTGCTCAACAACCTGCTGCCCCATGCCATCAACCTGCGGGAAGTC
AACCTGCGTCCCCAGATGTCCCAGTTCCTCTGCCTTAAGAATATCCGCACCTTTCTGTCT
ACCTGCTACGAGAAGTTTGGCCTCAAGCGGAGTGAACTCTTTGAGGCCTTCGACCTCTTC
GATGTGCAGGATTTTGGCAAGGTCATCTACACCCTGTCCGCTCTGTCCTGGACCCCGATT
GCCCAGAACAAGGGGATCATGCCCTTCCCCACTGAGGAGAGTGTGGGTGATGAAGACATC
TACAGTGGCCTGTCCGACCAGATCGACGACACGGTGGAGGAGGATGAGGACCTGTACGAC
TGCGTGGAGAACGAGGAGGCAGAGGGCGACGAGGTCTACGAGGACCTCATGCGCTCGGAG
CCGGTGCCCATGCCGCCCAAGATGACAGAGTATGACAAGCGGTGCTGCTGTCTGCGGGAG
ATCCAGCAGACGGAGGAGAAGTATACGGACACGCTGGGCTCCATCCAACAGCATTTTATG
AAGCCCTTGCAGCGGTTCCTTAAACCCCAAGACGTCGAGATTATCTTCATCAACATTGAG
GACCTGCTTCGTGTACACACCCATTTCCTAAAGGAGATGAAGGAAGCCCTGGCCAACCCT
GGTGCATCCACCCTCTACCAGGTCTTCATCAAATACAAGGAGAGGTTCCTCATCTATGGC
CGCTACTGTAGCCAGGTGGAGTCTGCCAGCAAGCACCTGGACCGTGTGGCCACAGCCCGG
GAGGATGTACAAATGAAGCTGGAAGAATGTAGTCAGCGCGCCAACAACGGGAGGTTCACC
TTAAGGGACCTGTTGATGGTGCCCATGCAGCGAGTGCTCAAATATCACCTCCTGCTCCAG
GAGCTGGTGAAACACACACAGGATGCAATGGAGAAGGACAACTTGCGGCTGGCCCTAGAT
GCCATGAGGGACCTGGCACAGTGCGTAAACGAGGTCAAGCGGGACAATGAGACGCTGCGG
CAGATTACCAACTTCCAGCTGTCCATCGAGAACCTGGACCAGTCTCTAGCCCACTACGGC
CGACCCAAGATCGATGGTGAGCTGAAGATAACTTCGGTGGAGAGGCGCTCCAAGATGGAC
AGGTATGCCTTCCTGCTTGACAAAGCTCTGCTCATCTGTAAGCGCCGAGGGGACACCTAC
GACCTCAAGGACTTTGTGAACCTGCACAGCTTCCAGGTTCGAGATGACTCCTCCGGAGAG
AGGGACAACAAGAAGTGGACTCACATGTTCCTCCTGATTGAGGACCAAGGTGCCCAGGGC
TATGAGCTGTTCTTCAAGACACGAGAACTAAAGAAGAAGTGGATGGAGCAGTTCGAGATG
GCCATCTCCAACATCTACCCCGAGAACGCCACTGCCAATGGTCATGACTTTCAGATGTTT
TCCTTTGAGGAGACCACATCCTGCAAGGCTTGCCAGATGCTGCTGAGAGGCACTTTCTAT
CAGGGGTACCGCTGTCAACGGTGCCGAGCACCTGCACACAAGGAGTGTCTTGGGAGGGTC
CCTCCGTGTGGTCGACATGGACAAGATTATTCAGGAACTATGAAGAAGGATAAGCCACAT
CGGCGGGCTCAAGACAAAAAGAGGAATGAGCTAGGCCTGCCCAAGATGGAGGTGTGCCAG
GAATACTACGGGCTGCCCCCACCCCCTGGAGCCATTGGACCTTTTTTGCGCCTCAACCCG
GGAGACATTGTGGAGCTCACTAAGGCTGAAGCCGAACAGAACTGGTGGGAGGGAAGGAAT
ATATCTACCAATGAAGTCGGCTGGTTTCCCTGCAATAGGGTCAAGCCCTACGTGCATGGT
CCCCCTCAGGACCTGTCCGTTCATCTCTGGTACGCTGGCCCCATGGAGCGAGCCGGGGCG
GAAAGCATTCTTACCAACCGCTCGGATGGGACGTTCTTGGTGCGGCAGAGGGTGAAGGAT
GCCGCGGAATTTGCCATCAGTATTAAGTATAATGTTGAAGTCAAGCATATTAAAATCATG
ACAGCAGAAGGACTGTACCGGATTACAGAAAAGAAAGCTTTCAGGGGACTTACGGAGCTG
GTGGAATTCTACCAACAGAACTCTCTGAAGGATTGCTTCAAGTCGCTGGACACCACCCTG
CAGTTCCCCTTCAAGGAGCCTGAGAGGAGAGCCATCAACAAACCATCAGCCGGGAGCATC
AAGATCTTTGGCACTGCTAAAGCCCGCTATGACTTCTGCGCCCGGGACCGGTCAGAGCTG
TCCCTCAAAGAGGGCGACATCGTCAAGATCCTTAACAAGAAGGGGCAGCAGGGCTGGTGG
CGAGGGGAGATCTATGGCCGGATTGGCTGGTTCCCCTCCAACTATGTGGAAGAGGACTAT
TCTGAGTACTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 844 |
| Molecular Weight
| 98243.0 |
| Theoretical pI
| 6.63 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Proto-oncogene vav
MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
NLRPQMSQFLCLKNIRTFLSTCYEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
AQNKGIMPFPTEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEVYEDLMRSE
PVPMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDVEIIFINIE
DLLRVHTHFLKEMKEALANPGASTLYQVFIKYKERFLIYGRYCSQVESASKHLDRVATAR
EDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDAMEKDNLRLALD
AMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMD
RYAFLLDKALLICKRRGDTYDLKDFVNLHSFQVRDDSSGERDNKKWTHMFLLIEDQGAQG
YELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFY
QGYRCQRCRAPAHKECLGRVPPCGRHGQDYSGTMKKDKPHRRAQDKKRNELGLPKMEVCQ
EYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNISTNEVGWFPCNRVKPYVHG
PPQDLSVHLWYAGPMERAGAESILTNRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIM
TAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPERRAINKPSAGSI
KIFGTAKARYDFCARDRSELSLKEGDIVKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDY
SEYC
|
| External Links |
|---|
| GenBank ID Protein
| AAI23647.1 |
| UniProtKB/Swiss-Prot ID
| Q08DN7 |
| UniProtKB/Swiss-Prot Entry Name
| VAV_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC123646 |
| GeneCard ID
| VAV1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
