| Identification |
|---|
| BMDB Protein ID
| BMDBP02669 |
| Secondary Accession Numbers
| None |
| Name
| Kappa-type opioid receptor |
| Synonyms
|
Not Available
|
| Gene Name
| OPRK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in kappa-opioid receptor activity |
| Specific Function
| G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| OPRK1 |
| Gene Sequence
|
>1143 bp
ATGGAGCCCCCAGTCCAGATCTTCCGCGGTGAGCCGGGCCCCACCTGCTCCCCGAGCACC
TGCCTGCCCCCCAACGGCAGCGGCTGGTTCCCGGGCTGGGCAGAGCCGGACGGTAACGGC
AGCGCGGGCTCGGAGGACGTGCTGCTGGAGCCAGCTCACATCTCCCCGGTCATCCTGGTC
ATCATCACGGCTGTCTACTCCGTGGTGTTCGTCGTGGGTTTGGTGGGCAACTCCCTGGTC
ATGTTCGTGATCATCCGATACACAAAGATGAAGACAGCAACCAACATCTATATCTTCAAC
CTGGCTTTGGCAGATGCACTGGTGACCACAACTATGCCCTTCCAGAGCACGGTCTATTTG
ATGAACTCCTGGCCCTTTGGGGATGTGCTGTGCAAGGTGGTCATCTCCATCGACTACTAC
AACATGTTCACCAGCATCTTCACCTTGACCATGATGAGTGTGGACCGTTACATCGCCGTG
TGCCACCCCGTCAAGGCTCTTGACTTCCGCACACCCCTGAAGGCGAAGATCATCAACATC
TGTATCTGGATCCTGTCTTCATCTGTTGGCATCTCTGCCATAGTCCTTGGAGGAACCAAA
GTTAGGGAAGACATGGAAGTCATCGAATGCTCCCTACAGTTCCCAGATGACGACTACTCC
TGGTGGGACCTGTTCATGAAGGTCTGTGTCTTCGTCTTTGCCTTCGTCATCCCCGTCCTC
ATTATCATTGTCTGCTACACCCTCATGATCCTGCGGTTAAAGAGCGTCCGCCTCCTCTCC
GGCTCCCGAGAGAAAGACCGCAACCTGCGGCGGATCACCAGGCTCGTGCTGGTGGTGGTG
GCGGTCTTCGTCGTCTGCTGGACCCCCATCCACATTTTCATCCTCGTGGAGGCCCTGGGG
AGCACCGCCCACAGCACGGCTGCCCTCTCCAGCTACTACTTCTGCATCGCCCTGGGCTAC
ACCAACAGCAGCCTGAACCCCATTCTCTACGCCTTCCTTGACGAAAACTTCAAGCGGTGT
TTCCGGGACTTCTGCTTTCCCATTAAGATGAGGATGGAGCGCCAGAGCACAAGCAGGGTC
AGAAATACCGTTCAGGATCCTGCCTACGTGAGGGAGGTTGATGGGGTAAATAAACCAGTA
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 380 |
| Molecular Weight
| 42626.0 |
| Theoretical pI
| 7.79 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 58-85
- 96-119
- 133-154
- 174-196
- 223-247
- 275-296
- 312-333
|
| Protein Sequence
|
>Kappa-type opioid receptor
MEPPVQIFRGEPGPTCSPSTCLPPNGSGWFPGWAEPDGNGSAGSEDVLLEPAHISPVILV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKVVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWILSSSVGISAIVLGGTKVREDMEVIECSLQFPDDDYSWWDLFMKVCVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STAHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYVREVDGVNKPV
|
| External Links |
|---|
| GenBank ID Protein
| AAI12562.1 |
| UniProtKB/Swiss-Prot ID
| Q2KIP6 |
| UniProtKB/Swiss-Prot Entry Name
| OPRK_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112561 |
| GeneCard ID
| OPRK1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
