<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:32:42 UTC</creation_date>
  <update_date>2020-05-20 21:06:22 UTC</update_date>
  <accession>BMDBP02679</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>CNGA1</gene_name>
  <general_function>Translation, ribosomal structure and biogenesis</general_function>
  <specific_function>Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0001314</accession>
      <name>Cyclic GMP</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>6</chromosome_location>
    <locus/>
    <gene_sequence>&gt;2073 bp
ATGAAGAAAGTGATTATCAATACATGGCACTCTTTTGTAAATATTCCCAATGTGGTTGGA
CCAGATGTTGAAAAGGAAATAACAAGGATGGAAAATGGAGCATGCAGCTCCTTTTCTGGT
GATGATGACGACAGTGCCTCTATGTTTGAAGAATCAGAGACTGAGAACCCCCACGCAAGG
GATTCCTTTAGAAGTAATACACACGGAAGCGGACAACCATCACAGAGGGAGCAATACCTG
CCTGGAGCCATTGCACTTTTTAATGTTAACAACAGCAGCAATAAGGAGCAAGAACCAAAG
GAAAAGAAGAAAAAGAAAAAAGAAAAGAAGAGCAAGCCAGATGATAAAAATGAAAATAAA
AAGGACCCAGAAAAGAAAAAGAAGAAAGAAAAGGACAAAGACAAGAAAAAGAAAGAGGAG
AAAGGCAAAGATAAGAAAGAGGAAGAGAAGAAGGAAGTCGTGGTTATTGATCCCTCAGGA
AATACGTATTACAACTGGCTGTTCTGCATCACCTTACCTGTTATGTATAACTGGACCATG
ATTATTGCAAGAGCATGTTTTGATGAACTTCAGTCTGATTACCTAGAATACTGGCTTGCT
TTTGATTACTTATCAGATGTAGTCTATCTTCTTGATATGTTTGTACGAACAAGGACAGGT
TACCTAGAACAAGGACTACTGGTGAAGGAAGAGCGTAAACTCATAGACAAGTATAAATCA
ACCTTTCAATTTAAACTTGATGTTCTATCAGTGATCCCAACTGATCTGCTGTATATTAAG
TTTGGCTGGAATTATCCAGAAATTAGATTAAACAGATTGTTAAGGATCTCTCGAATGTTT
GAGTTCTTCCAGAGAACAGAAACACGGACAAACTACCCAAACATCTTCAGGATCTCTAAC
CTTGTCATGTACATCATCATCATCATCCACTGGAATGCGTGTGTGTACTTCTCTATTTCC
AAAGCTATTGGGTTTGGAAATGACACATGGGTCTATCCTGATGTTAATGATCCTGATTTT
GGCCGTTTGGCTAGAAAATATGTGTACAGTCTTTACTGGTCTACACTGACTTTGACCACT
ATTGGCGAAACACCACCTCCTGTGAGGGATTCTGAGTATTTCTTTGTGGTGGCTGATTTC
CTCATTGGAGTGTTAATTTTTGCCACCATTGTCGGTAACATAGGTTCTATGATTTCCAAC
ATGAATGCGGCCAGGGCAGAATTTCAAGCAAGAATTGATGCAATCAAGCAATACATGCAT
TTTCGAAATGTAAGCAAAGATATGGAGAAGCGAGTCATTAAATGGTTTGACTATCTGTGG
ACCAACAAAAAAACAGTGGATGAGAGAGAAGTCTTGAAGTATCTACCTGATAAACTAAGA
GCAGAGATCGCCATCAATGTTCATTTAGACACATTAAAAAAGGTGCGCATTTTTGCAGAC
TGTGAAGCTGGTCTGTTGGTGGAGTTGGTCTTGAAATTACAACCCCAAGTCTACAGTCCT
GGAGATTACATTTGCAAGAAAGGGGACATTGGCCGAGAGATGTACATCATCAAGGAAGGC
AAACTCGCCGTGGTGGCTGATGACGGGATCACTCAGTTTGTAGTATTGAGTGATGGCAGC
TACTTTGGTGAAATCAGTATCCTTAATATTAAAGGTAGCAAAGCTGGCAATCGAAGAACA
GCCAATATTAAAAGCATTGGCTACTCAGATCTATTCTGTCTCTCAAAAGATGACCTCATG
GAAGCTCTAACTGAGTACCCAGATGCCAAAGGTATGCTAGAAGAGAAAGGGAAGCAAATT
TTGATGAAAGATGGTCTATTGGACATAAACATTGCAAATGCTGGAAGTGATCCTAAAGAT
CTTGAAGAGAAGGTCACCCGAATGGAGAGCTCAGTAGACCTCCTGCAAACAAGGTTTGCT
CGGATCCTGGCTGAGTATGAGTCAATGCAGCAGAAACTGAAGCAGAGGCTAACCAAGGTT
GAGAAATTCCTGAAACCACTTATTGACACAGAATTTTCAGCTATTGAAGGATCTGGAACT
GAAAGTGGGCCCACAGACTCTACACAGGACTGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>690</residue_number>
    <molecular_weight>79602.0</molecular_weight>
    <theoretical_pi>7.08</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>163-183</region>
      <region>197-215</region>
      <region>238-257</region>
      <region>265-286</region>
      <region>298-324</region>
      <region>368-399</region>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;cGMP-gated cation channel alpha-1
MKKVIINTWHSFVNIPNVVGPDVEKEITRMENGACSSFSGDDDDSASMFEESETENPHAR
DSFRSNTHGSGQPSQREQYLPGAIALFNVNNSSNKEQEPKEKKKKKKEKKSKPDDKNENK
KDPEKKKKKEKDKDKKKKEEKGKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTM
IIARACFDELQSDYLEYWLAFDYLSDVVYLLDMFVRTRTGYLEQGLLVKEERKLIDKYKS
TFQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISN
LVMYIIIIIHWNACVYFSISKAIGFGNDTWVYPDVNDPDFGRLARKYVYSLYWSTLTLTT
IGETPPPVRDSEYFFVVADFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMH
FRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLKYLPDKLRAEIAINVHLDTLKKVRIFAD
CEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGS
YFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKGMLEEKGKQI
LMKDGLLDINIANAGSDPKDLEEKVTRMESSVDLLQTRFARILAEYESMQQKLKQRLTKV
EKFLKPLIDTEFSAIEGSGTESGPTDSTQD</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>CAA35947.1</genbank_protein_id>
  <uniprot_id>Q00194</uniprot_id>
  <uniprot_name>CNGA1_BOVIN</uniprot_name>
  <pdb_ids>
    <pdb_id>3SWF</pdb_id>
    <pdb_id>3SWF</pdb_id>
  </pdb_ids>
  <genbank_gene_id>X51604</genbank_gene_id>
  <genecard_id>CNGA1</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
