| Identification |
|---|
| BMDB Protein ID
| BMDBP02719 |
| Secondary Accession Numbers
| None |
| Name
| Endoplasmic reticulum resident protein 44 |
| Synonyms
|
Not Available
|
| Gene Name
| ERP44 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| ERP44 |
| Gene Sequence
|
>1221 bp
ATGATTCCTGGCATCTTCCTATCCTTACCCGATCTCAGATGCTCCCTGCTTCTCCTGGTA
ACTTGGGTTTTTACTCCTGTAACAGCTGAAATAATAAGTCTTGATACAGAGAATATAGAT
GACATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTTATGCTGATTGGTGTCGTTTC
AGCCAGATGTTGCACCCAATTTTTGAGGAAGCTTCCAATGTCATTAAGGAAGAATACCCA
AATGCAAATCAAGTAGTCTTTGCCAGAGTTGATTGTGATCAGCACTCTGATATAGCCCAG
AGATATAGGATAAGCAAATACCCAACCCTCAAGTTGTTTCGTAATGGGATGATGATGAAG
AGAGAATACAGGGGTCAGCGATCAGTGAAAGCACTTGCAGATTACATCAGGCAACAAAAA
AGTGACCCCATTCAAGAACTTCATGACTTGGCAGAAATCACCACTCCTGACCGCAGCAAA
AGAAATATCATTGGATATTTTGAGCAGAAGGATTCAGAAAACTATAGAGTTTTTGAAAGA
GTAGCAAATATTTTGCATGATGATTGTGCCTTCCTAGCTGCGTTTGGGGTTGTTTCAAAA
CCAGAAAGATACAGTGGAGACAACATAGTCTATAAGCCACCAGGGCATTCTGCTCCAGAT
ATGGTGTACTTGGGATCTATGACAAATTTTGATGGGACTTACAATTGGATTCAAGATAAA
TGCGTTCCTCTTGTCAGAGAAATAACATTTGAAAATGGAGAGGAACTGACAGAAGAAGGA
CTGCCTTTTCTCATACTCTTCCACATGAAAGAAGATACAGAAAGTTTAGAAATATTCCAG
AATGAAGTAGCCCGACAATTAATAAGTGAAAAAGGTACAATAAACTTTTTACATGCTGAC
TGTGACAAATTTAGACATCCTCTTCTGCACATACAGAAAACTCCAGCAGATTGCCCTGTA
ATAGCTATCGACAGCTTTAGGCACATGTATGTGTTTGGAGACTTCAGGGATGTATTAATT
CCTGGAAAACTCAAGCAGTTTGTATTTGACTTACATTCTGGAAAGCTACACAGAGAATTC
CATCATGGTCCTGACCCAACTGATACAGCCCCAGGAGAGGAAGTCCAGGATGTCGCAAGC
AGTCCACCTGAGAGCTCCTTCCAGAAACTAGCACCCAGTGAATATAGGTATACTCTATTG
AGGGATCGAGATGAGCTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 406 |
| Molecular Weight
| 46836.0 |
| Theoretical pI
| 4.95 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 221-241
- 249-269
- 291-309
- 346-368
- 378-399
- 478-498
|
| Protein Sequence
|
>Endoplasmic reticulum resident protein ERp44
MIPGIFLSLPDLRCSLLLLVTWVFTPVTAEIISLDTENIDDILNNADVALVNFYADWCRF
SQMLHPIFEEASNVIKEEYPNANQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMK
REYRGQRSVKALADYIRQQKSDPIQELHDLAEITTPDRSKRNIIGYFEQKDSENYRVFER
VANILHDDCAFLAAFGVVSKPERYSGDNIVYKPPGHSAPDMVYLGSMTNFDGTYNWIQDK
CVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHAD
CDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFRDVLIPGKLKQFVFDLHSGKLHREF
HHGPDPTDTAPGEEVQDVASSPPESSFQKLAPSEYRYTLLRDRDEL
|
| External Links |
|---|
| GenBank ID Protein
| AAI02350.1 |
| UniProtKB/Swiss-Prot ID
| Q3T0L2 |
| UniProtKB/Swiss-Prot Entry Name
| ERP44_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102349 |
| GeneCard ID
| ERP44 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
