| Identification |
|---|
| BMDB Protein ID
| BMDBP02767 |
| Secondary Accession Numbers
| None |
| Name
| Homer protein homolog 1 |
| Synonyms
|
Not Available
|
| Gene Name
| HOMER1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| HOMER1 |
| Gene Sequence
|
>1065 bp
ATGGGGGAACAACCCATCTTCAGCACTCGAGCTCATGTCTTCCAGATCGACCCAAACACA
AAGAAGAACTGGGTGCCCACCAGCAAGCATGCAGTTACTGTGTCTTATTTCTATGACAGC
ACAAGAAACGTGTATAGGATAATCAGTTTAGACGGCTCAAAGGCAATAATTAACAGCACC
ATCACTCCAAACATGACATTTACTAAAACATCTCAGAAGTTTGGCCAGTGGGCCGATAGC
AGGGCAAACACTGTTTATGGACTGGGGTTCTCCTCTGAGCATCATCTTTCGAAATTTGCA
GAAAAGTTTCAGGAATTTAAAGAAGCTGCTCGACTAGCAAAGGAGAAATCACAAGAAAAG
ATGGAACTTACCAGTACACCTTCACAGGAATCAGCAGGTGGGGATCTTCAGTCTCCTTTA
ACACCAGAAAGCATCAACGGGACAGATGATGAGAGAACACCTGATCTGACGCAGAACTCG
GAGCCGCGGCCTGAACCCACCCAGAACGCACTGCCGTTCACACATAGTTCAGCAATCAGC
AAACACTGGGAGGCTGAACTGGCCACCCTCAAAGGAAACAATGCCAAACTCACTGCAGCC
CTGCTGGAGTCTACTGCCAATGTGAAACAATGGAAGCAGCAGCTTGCTGCCTATCAGGAG
GAAGCAGAGCGGCTGCACAAGCGGGTGACTGAGCTTGAATGTGTTAGTAGCCAAGCAAAT
GCAGTGCATACCCATAAGACAGAACTAAATCAGACAATACAAGAACTGGAGGAGACGCTG
AAGGTGAAGGAAGAGGAAATAGAAAGATTAAAACAAGAAATTGATAATGCCAGAGAACTA
CAAGAACAGAGGGACTCTTTGACTCAGAAACTACAGGAAGTAGAAATTCGGAACAAAGAC
CTGGAGGGACAACTGTCTGACTTAGAGCAACGTCTGGAGAAAAGTCAGAATGAACAAGAA
GCTTTTCGCAATAACCTGAAGACCCTGTTAGAAATCCTTGATGGAAAAATCTTTGAACTA
ACAGAATTACGAGATAACTTGGCCAAGCTACTAGAACGCAGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 40370.0 |
| Theoretical pI
| 5.25 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 185-205
- 227-247
- 262-282
- 292-312
- 326-346
- 387-407
|
| Protein Sequence
|
>Homer protein homolog 1
MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINST
ITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEK
MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDLTQNSEPRPEPTQNALPFTHSSAIS
KHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQAN
AVHTHKTELNQTIQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKD
LEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLERS
|
| External Links |
|---|
| GenBank ID Protein
| AAI05510.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJ56 |
| UniProtKB/Swiss-Prot Entry Name
| HOME1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC105509 |
| GeneCard ID
| HOMER1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
