| Identification |
|---|
| BMDB Protein ID
| BMDBP02824 |
| Secondary Accession Numbers
| None |
| Name
| Voltage-dependent L-type calcium channel subunit beta-1 |
| Synonyms
|
Not Available
|
| Gene Name
| CACNB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Regulatory subunit of L-type calcium channels (PubMed:10684870). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:10684870). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| CACNB1 |
| Gene Sequence
|
>1797 bp
ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCATCCTCCCAGGAGATCCCCATG
GAGGTCTTCGACCCCAGCCCACAGGGCAAATACAGCAAGAGGAAAGGGCGGTTCAAAAGG
TCGGATGGGAGCACATCCTCGGATACAACATCCAACAGCTTTGTCCGCCAGGGCTCAGCA
GAGTCCTACACCAGCCGTCCGTCAGACTCTGATGTGTCTCTGGAGGAGGACCGGGAAGCC
TTAAGGAAGGAGGCAGAGCGTCAGGCGTTAGCCCAGCTAGAGAAAGCCAAGACCAAGCCG
GTGGCATTTGCTGTGCGGACAAATGTCGGCTACAACCCATCTCCAGGGGATGAGGTGCCT
GTGCAGGGAGTGGCCATCACCTTCGAGCCTAAGGACTTCCTACACATCAAAGAGAAATAC
AATAATGACTGGTGGATCGGGCGACTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATCCCC
AGCCCTGTCAAACTGGACAGCCTGCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC
CTCAGCTCCAGCAAATCAGGTGACAACTCCAGCTCCAGCCTGGGAGACGTGGTGACTGGC
ACCCGCCGCCCCACGCCCCCTGCCAGTGCCAAACAGAAGCAGAAGTCGACAGAACACGTG
CCCCCTTATGACGTGGTACCTTCCATGAGGCCCATTATCCTGGTGGGACCGTCGCTGAAG
GGCTATGAGGTTACAGATATGATGCAGAAAGCTTTATTTGACTTCTTGAAGCATCGGTTT
GATGGCAGGATCTCCATCACACGTGTGACAGCGGACATTTCCCTGGCTAAGCGATCAGTC
CTCAACAACCCCAGCAAACACATCATCATCGAGCGTTCCAACACACGCTCCAGCCTGGCT
GAGGTTCAGAGCGAGATCGAGCGGATCTTTGAGCTAGCCCGAACCCTTCAGTTGGTTGCT
CTGGACGCCGACACCATCAACCATCCAGCCCAGCTCTCCAAGACCTCACTGGCCCCCATC
ATTGTTTACATCAAGATCACCTCTCCTAAGGTTCTTCAGAGGCTCATCAAGTCTCGAGGG
AAGTCTCAGTCCAAACACCTCAACGTCCAAATAGCGGCCTCAGAGAAACTGGCGCAGTGT
CCCCCTGAGATGTTTGACATCATCCTGGATGAGAACCAATTGGAGGACGCCTGCGAGCAC
TTGGCAGAGTACTTGGAAGCCTATTGGAAGGCTACACACCCGCCCAGCAGCACTCCGCCC
AATCCGCTGCTGAACCGCACCATGGCTACTGCAGCCCTGGCTGCCAGCCCTGCCCCTGTC
TCCAACCTCCAGGGACCCTACCTTGCTTCCGGGGACCAGTCGCTGGAACGGGCCACGGGG
GAGCACGCCAGTGTGCACGAGTACCCGGGAGAGCTGGGCCAGCCCCCAGGCCTTTACCCC
AGCAGCCACCCGCCAGGCCGGGCGGGCACCCTGCGGGCACTGTCCCGCCAAGACACGTTT
GATGCTGACACCCCTGGCAACCGAAACTCTGCCTACACGGAGCTGGGAGACTCGTGTGTG
GACATGGAGACTGACCCCTCCGAGGGGCCAGGGCTTGGAGACCCTGCAGGGGGCAGCACC
CCACCAGCCCGACAGGGATCCTGGGAGGATGAGGAAGAAGACTATGAAGAGGAGCTGACC
GACAACCGGAACCGCGGCCGGAATAAGGCCCGCTACTGCGCGGAGGGCGGGGGCCCAGTT
CTGGGGCGCAACAAGAACGAGCTGGAGGGTTGGGGGCGGGGTGTCTACATCCGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 598 |
| Molecular Weight
| 65749.0 |
| Theoretical pI
| 6.75 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 451-470
- 482-499
- 511-530
- 551-571
- 591-614
- 635-658
- 664-687
|
| Protein Sequence
|
>Voltage-dependent L-type calcium channel subunit beta-1
MVQKTSMSRGPYPSSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSA
ESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVP
VQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR
LSSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLK
GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA
EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG
KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP
NPLLNRTMATAALAASPAPVSNLQGPYLASGDQSLERATGEHASVHEYPGELGQPPGLYP
SSHPPGRAGTLRALSRQDTFDADTPGNRNSAYTELGDSCVDMETDPSEGPGLGDPAGGST
PPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR
|
| External Links |
|---|
| GenBank ID Protein
| AAF26679.1 |
| UniProtKB/Swiss-Prot ID
| Q9MZL7 |
| UniProtKB/Swiss-Prot Entry Name
| CACB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF174415 |
| GeneCard ID
| CACNB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
