1.0 2018-05-07 22:33:23 UTC 2020-05-20 21:04:45 UTC BMDBP02830 Enzyme FGG Involved in calcium ion binding Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. Coagulation SMP0119377 BMDB0000464 Calcium 17 17q12-q13 >1335 bp ATGAGTTGGTCCTCGCACCCTCCGAGTGTAATCTTCTACATTCTTTCATTGCTTTCTTCA GCATGCCTGGCATATGTTGCTACCCGAGACAACTGCTGCATCTTAGATGAAAGATTTGGT AGTTATTGCCCAACTACCTGTGGAATTGCAGATTTCCTGAATAATTACCAAACCAGTGTA GACAAAGATCTACGAACTTTGGAAGGCATCTTATATCAGGTTGAGAACAAAACATCAGAA GCCAGAGAGCTGGTCAAAGCAATCCAAATCAGCTATAACCCTGATCAACCATCAAAGCCA AATAACATAGAGAGTGCTACCAAGAATTCCAAGAGTATGATGGAAGAAATTATGAAATAT GAAACACTGATATCAACACATGAATCAACAATTCGATTTTTGCAAGAGGTATATAACTCA AATAGTCAAAAAATCGTTAACCTAAGAGATAAAGTGGTCCAGCTTGAAGCAAACTGTCAA GAGCCTTGTCAAGATACAGTGAAAATACATGATGTAACTGGGAGAGATTGCCAAGATGTT GCCAATAAGGGGGCCAAAGAGAGTGGACTTTACTTTATCAGACCTCTGAAAGCTAAGCAG TTCTTAGTCTACTGTGAAATTGATGGGTCTGGAAATGGATGGACTGTGTTTCAGAAGAGG CTTGATGGCAGTCTGGATTTCAAGAAAAACTGGATTCAATATAAAGAAGGGTTTGGACAT CTGTCTCCTACTGGTACTGGAAACACAGAATTTTGGCTGGGAAATGAGAAGATTCATTTG ATAAGCACACAGTCATCCATCCCTTATGTATTAAGAATACAGTTGGAGGACTGGAATGGC AGAACCAGCACTGCAGATTATGCTTCATTCAAGGTGACAGGTGAAAATGACAAATACCGC CTGACATATGCTTACTTCATTGGTGGAGATGCTGGAGATGCATTTGATGGCTACGATTTT GGCGATGATTCTAGTGACAAGTTTTTCACATCCCATAATGGCATGCAGTTCAGTACTTGG GACAGTGACAATGATAAGTATGATGGCAACTGTGCTGAACAGGTAGGTATCGGTTGGTGG ATGAACAAATGTCACGCTGGCCACCTCAATGGAGTTTATTATCAAGGTGGCACTTACTCA AAAACATCTACTCCTAATGGTTATGATAATGGCATTATTTGGGCCACATGGAAATCCCGG TGGTATTCCATGAAGAAAACCACCATGAAGATAATCCCACTTAACAGACTTGCCATCGGA GAAGGACAGCAGCACCAACTGGGGGGAGCCAAACAGGTCGGAGTAGAACATCACGTTGAA ATAGAATATGACTAA 444 50244.0 5.62 1-24 >Fibrinogen gamma-B chain MSWSSHPPSVIFYILSLLSSACLAYVATRDNCCILDERFGSYCPTTCGIADFLNNYQTSV DKDLRTLEGILYQVENKTSEARELVKAIQISYNPDQPSKPNNIESATKNSKSMMEEIMKY ETLISTHESTIRFLQEVYNSNSQKIVNLRDKVVQLEANCQEPCQDTVKIHDVTGRDCQDV ANKGAKESGLYFIRPLKAKQFLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGH LSPTGTGNTEFWLGNEKIHLISTQSSIPYVLRIQLEDWNGRTSTADYASFKVTGENDKYR LTYAYFIGGDAGDAFDGYDFGDDSSDKFFTSHNGMQFSTWDSDNDKYDGNCAEQVGIGWW MNKCHAGHLNGVYYQGGTYSKTSTPNGYDNGIIWATWKSRWYSMKKTTMKIIPLNRLAIG EGQQHQLGGAKQVGVEHHVEIEYD CAA33562.1 P12799 FIBG_BOVIN 1DEQ 1JY2 1JY3 1JY2 1JY3 X15556 FGG