| Identification |
|---|
| BMDB Protein ID
| BMDBP00536 |
| Secondary Accession Numbers
| |
| Name
| Thymidylate synthase |
| Synonyms
|
Not Available
|
| Gene Name
| TYMS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. |
| Pathways
|
- DTTP biosynthesis
- Pyrimidine Metabolism
|
| Reactions
|
| dUMP + 5,10-Methylene-THF → 5-Thymidylic acid + Dihydrofolic acid |
details
|
| 5-Thymidylic acid + Adenosine triphosphate → dTDP + ADP |
details
|
| dUMP + Adenosine triphosphate → dUDP + ADP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 24 |
| Locus
| Not Available |
| SNPs
| TYMS |
| Gene Sequence
|
>1065 bp
ATGCCAGCGGCCGGCTCCGAGCCGTCGCGCCCGCCGTCGCCGCCCGGCGTGCAGGAGCAG
AGCGCCGAGCCGCGGCCGCCGCCGCCGCCGCACGGGGAGCTGCAGTACCTGGGGCAGATA
GAACACATCCTCCGCTGCGGCTTCCGGAGGGATGACCGCACCGGCACTGGCACCCTGTCG
GTGTTCGGGATGCAGGCGCGGTACAACTTGAGAGATGAATTTCCTCTGCTGACAACCAAA
CGTGTTTTCTGGAAAGGTGTTTTGGAGGAGTTGCTGTGGTTTATCAAGGGATCCACCAAC
GCTAAGGAACTCTCTTCCAAGGGAGTGAAAATTTGGGATGCCAATGGGTCCCGAGACTTC
TTGGATGGCCTGGGCTTCTCCGACAGAGCTGAAGGGGATTTAGGCCCAGTTTATGGCTTC
CAGTGGAGGCATTTTGGGGCTGAATACAAAGATATGGATTCAGAGTATTCAGGTCAAGGA
GTAGATCAACTGCAAAAAGTGATCGACACAATCAAAACCAACCCTAACGACAGAAGAATC
ATCCTGTGTGCTTGGAATCCAAAAGATCTGCCTCTCATGGCCCTCCCCCCATGCCACGCC
CTCTGCCAGTTCTACGTGGTGAATGGGGAGTTGTCCTGCCAGTTGTACCAGCGGTCGGGG
GACATGGGCCTGGGTGTGCCCTTCAACATTGCCAGCTACGCCCTGCTCACCTACATGATC
GCACACATCACGGACCTGAAGCCAGGTGACTTCGTGCACACTCTGGGAGATGCACACATT
TACCTGAATCACATCGAGCCACTGAAAACTCAGGCTCTGATGGAGCTAAGAGGACAGTCT
TCCAGGTCTCTGGATGGTGATGGACAGGCAGGGACCAGCAGATGGGCCCCAGTGGCCACA
GACACTGAACGTGACAGGTGCTGTGAGCTGCAGCGAGAACCAAGGCCTTTCCCCAAGCTC
AAAATCCTTCGAAAAGTTGAGACAATCGATGACTTCCAGGCCGAAGACTTTCAGATTGAA
GGCTACAATCCTAATCCGACTATTAAAATGGAAATGGCTGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 39785.0 |
| Theoretical pI
| 5.66 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thymidylate synthase
MPAAGSEPSRPPSPPGVQEQSAEPRPPPPPHGELQYLGQIEHILRCGFRRDDRTGTGTLS
VFGMQARYNLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDF
LDGLGFSDRAEGDLGPVYGFQWRHFGAEYKDMDSEYSGQGVDQLQKVIDTIKTNPNDRRI
ILCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMI
AHITDLKPGDFVHTLGDAHIYLNHIEPLKTQALMELRGQSSRSLDGDGQAGTSRWAPVAT
DTERDRCCELQREPRPFPKLKILRKVETIDDFQAEDFQIEGYNPNPTIKMEMAV
|
| External Links |
|---|
| GenBank ID Protein
| AAI11140.1 |
| UniProtKB/Swiss-Prot ID
| Q2TA32 |
| UniProtKB/Swiss-Prot Entry Name
| TYSY_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC111139 |
| GeneCard ID
| TYMS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
