| Identification |
|---|
| BMDB Protein ID
| BMDBP02145 |
| Secondary Accession Numbers
| None |
| Name
| Angiopoietin-related protein 4 |
| Synonyms
|
Not Available
|
| Gene Name
| ANGPTL4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in receptor binding |
| Specific Function
| Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| ANGPTL4 |
| Gene Sequence
|
>1233 bp
ATGCGCTGTGCGCCGACAGCCGGAGCAGCCCTGATGCTGTGCGCCGCCACCGCCGGGCTG
CTGAGCGCTCAGGGCCGCCCGGAGCCTCCCGAGACGCCGCGCTTTGCTTCCTGGGACGAG
GTGAACGTGCTGGCACACGGCCTCTTGCAGCTCGGCCACGGGCTGCGCGAACACGTGGAG
CGCACCCGTGGGCAGCTGGGCGAGCTGGAACGGCGTCTGGGCGCGTGTGGGGCCGCCTGC
AAGGATCCTGAGGGGTCCGCCGCGCCTCCGCGTGCCCAGGCCAATTTGGTCAATCCCGGC
GGCGGCGACGCCTCCCCAGAAACCCTCCGCAGCTTGAAGACTCAGCTGGAGGCTCAGAAC
AGCAGGATCCAGCAACTCTTCCAGAAGGTGGCCCAGCAGCAGCGGCACTTGGAGAAGCAG
CAGCTGCGAATCCAGAATCTACAGAGCCAGATGGATCACCTGGCCCCCAGGCACCTGGGC
CACGAGATGGCCAAGCCCGCCAGGAGGAAGAGGCTGCCCAAGATGGCCCAGCTTGCTGGC
CCAGCTCACAATATCAGCCGCCTGCACAGACTGCCCAGGGACTGCCAGGAGCTGTTTGAA
GAGGGAGAGAGGGAAAGTGGATTGTTCCAGATCCAGCCCCAGGGATCCCCGCCTTTCCTG
GTTAACTGCAAAATGACCTCAGATGGAGGCTGGACCGTAATTCAGAGGCGTCAGGATGGC
TCCGTGGACTTTAACCAGCCCTGGGAAGCCTACAAAGATGGCTTCGGAGACCCCCAAGGC
GAGTTCTGGCTGGGCCTGGAGAAGGTGCATCACATCCTTGGGGACCGTGGCAGCCGCCTG
GCTGTGCAGCTGCAGGACTGGGAGGGCAATGCCGAGTCCTTGCAGTTCCCCATCCACCTG
GGGGGTGAAGACACCGCCTACAGCCTGCAGCTCACGCCACCGGTGGCCAGCAAACTGGGC
GCCACCACCTTCTCGCCCAGTGGCCTCTCCCTGCCCTTCTCCACTTGGGACCAGGACCAC
GACCTCCGCGGAGACAAGAACTGCGCCAGGAGCCTCTCTGGTGGCTGGTGGTTTGGCACC
TGCAGTCACTCCAACCTGAACGGCCAGTATTTCCACTCCATTCCAAGGCAGCGGCAGCAG
CGTAAGAAGGGCATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCACTGCAGGCCACC
ACCATCCTGGTACAGCCCACAGCGGCCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 410 |
| Molecular Weight
| 45553.0 |
| Theoretical pI
| 8.93 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 35-56
- 62-85
- 167-186
- 198-218
- 230-250
- 262-287
- 294-315
- 321-338
|
| Protein Sequence
|
>Angiopoietin-related protein 4
MRCAPTAGAALMLCAATAGLLSAQGRPEPPETPRFASWDEVNVLAHGLLQLGHGLREHVE
RTRGQLGELERRLGACGAACKDPEGSAAPPRAQANLVNPGGGDASPETLRSLKTQLEAQN
SRIQQLFQKVAQQQRHLEKQQLRIQNLQSQMDHLAPRHLGHEMAKPARRKRLPKMAQLAG
PAHNISRLHRLPRDCQELFEEGERESGLFQIQPQGSPPFLVNCKMTSDGGWTVIQRRQDG
SVDFNQPWEAYKDGFGDPQGEFWLGLEKVHHILGDRGSRLAVQLQDWEGNAESLQFPIHL
GGEDTAYSLQLTPPVASKLGATTFSPSGLSLPFSTWDQDHDLRGDKNCARSLSGGWWFGT
CSHSNLNGQYFHSIPRQRQQRKKGIFWKTWRGRYYPLQATTILVQPTAAS
|
| External Links |
|---|
| GenBank ID Protein
| ABC84490.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJ51 |
| UniProtKB/Swiss-Prot Entry Name
| ANGL4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ355521 |
| GeneCard ID
| ANGPTL4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
