Phenotypes
Stenosis, spinal
No summary available.
Sterile, male, NANOS2-related
Ciccarelli et al. (2020) "show that male mice, pigs, goats, and cattle harboring knockout alleles of the NANOS2 gene generated by CRISPR-Cas9 editing have testes that are germline ablated but otherwise structurally normal. ... Collectively, these advancements represent a major step toward realizing the enormous potential of surrogate sires as a tool for dissemination and regeneration of germplasm in all mammalian species." These are geneticall...
Sterile, NANOS3-related
Mueller et al. (2023) "generated NANOS3 KO [knock-out] cattle via cytoplasmic microinjection of the CRISPR/Cas9 system in vitro produced bovine zygotes and evaluated the effect of NANOS3 elimination on bovine germline development, from fetal development through reproductive age. ... Overall, this study demonstrated that the absence of NANOS3 in cattle leads to the specific deficiency of both male and female germ cells, suggesting the potentia...
Stillbirth
Stillbirth occurs in many different forms, many of which are not inherited, some are multifactorial and others are single locus disorders.
Strabismus
No summary available.
Stringhalt
No summary available.
Syndactyly — Mule foot disease; mulefoot; Haplotype HHM
Syndactyly has been reported in many breeds of cattle in many countries. Most of the documentation, however, concerns its occurrence in US Holsteins, where, as a result of the siring of more than 60,000 calves by a bull who was subsequently shown to be a carrier, the disorder attracted considerable attention (Anon., 1967). The possibility that artificial selection favouring heterozygotes may have contributed to the unacceptably high frequency ...
Syndrome des veaux tourneurs (Turning calves syndrome)
Duchesne et al. (2017) identified SNPs in the mapped candidate region by comparison of whole-genome sequence of two homozygous affecteds, one heterozygote and one homozygote normal. Filtering of those SNPs by consistency with presumed genotype based on pedigree, with occurrence only within this breed, and by severity of presumed function enabled Duchesne et al. (2017) to identifiy a "C/T SLC25A46 substitution [c.376C>T that] leads to replac...
Syringomyelia
No summary available.
Tail abnormalities
No summary available.
Tail, crooked — Crooked tail syndrome
"Affected animals have a crooked tail and shortened head, growth retardation, extreme muscularity and spastic paresia, although some characteristics show variable penetrance. CTS is not lethal per se, but causes substantial economic losses due to growth retardation and treatment." (Charlier et al., 2008)
Tail, kinky
No summary available.
Tail, short
No summary available.
Tail, wry
No summary available.
Taillessness
No summary available.